課程名稱︰細胞生物學
課程性質︰生科系必修
課程教師︰陳俊宏(期末考範圍與李心予合授)
開課學院：生命科學院
開課系所︰生命科學系
考試日期（年月日）︰2017.06.21
考試時限（分鐘）：180分鐘(兩位老師考卷分開但時間一起算)
試題 :
1. The eukaryotic cell cycle is composed of four phases in the following order:
(A)G1;G2;S;M (B)G1;S;G2;M (C)G1;M;G2;S (D)S;G1;G2;M.
2. Maturation promotion factor (MFP) is the factor that
(A) induces entry of cell into meiosis.
(B) triggers cell to close the M phase by activation of a protein kinase.
(C) consists of three subunits: one kinase and two cyclins.
(D) sufficient cyclin-dependent kinase is synthesizd to trigger mitosis.
3. Entry into mitosis occurs because
(A) cyclin is destroyed at the beginning of mitosis.
(B) cyclin binds to a protein kinase and activates it.
(C) cyclin is phosphorylated at the beginning of mitosis.
(D) sufficient cyclin-dependent kinase is synthesized to trigger mitosis.
4. Chromosomes are attached to spindle microtubules by
(A) kinetochores (B) kinetosomes (C) centrioles (D) centrosomes.
5. p21 inhabits cell cycle progression by binding to and inhabiting
(A) cyclin-dependent kinases (B) Rb protein (C) p53 (D) ATM.
6. To prevent cells with unreplicated DNA from passing through the G2
checkpoint, CHK1 and CHK2 ______ and ______ protein phosphatase Cdc25.
(A) phosphorylate; stimulate (B) phosphorylate; inhabit
(C) dephosphorylate; stimulate (D) dephosphorylate; inhabit
7. To become active, Cdk1 must
(A) bind cyclin and be phosphorylated on tyrosine 15 and threonines 14 and 161
(B) bind cyclin and be phosphorylated on tyrosine 15, and be dephosphorylated
on threonines 14 and 161
(C) bind cyclin and be phosphorylated on threonine 161, and be dephosphorylated
threonine 14 and tyrosine 15
(D) be phosphorylated on threonine 161, be dephosphorylated on threonine 14 and
tyrosine 15, and form complexes with cyclin.
8. Which of the following sequence is correct?
(A) prophase → metaphase → telophase → anaphase
(B) metaphase → prophase → anaphase → telophase
(C) prophase → metaphase → anaphase → telophase
(D) prophase → telophase → metaphase → anaphase
9. In meiosis I, sister chromatids
(A) go to opposite poles
(B) go to the same poles
(C) have kinetochores facing in opposite directions
(D) synapse with each other during the zygotene stage
10. Cyclin B and ______ are ubiquinated and degraded by active APC/C.
(A) ubiquitin (B) condensin (C) securin (D) separase.
11. Which of the following is a false statement about innate immunity?
(A) They include T cells and B cells.
(B) They include inflammatory responses.
(C) They must be primed by the presence of antigen.
(D) Macrophages and natural killer cells are participants in the process.
12. Which of the following is most likely to be recognized by a particular
Toll-like receptors(TLRs) that defends against some viruses?
(A) phospholipids (B) lipopolysaccharides
(C) double-stranded DNA (D) double-stranded RNA
13. All of the following statements about clonal selection theory is correct
except
(A) The body selects which antigens it will respond to.
(B) Specific antigen activates specific clone of lymphocyes.
(C) Even identical twins have different immune responses.
(D) Only certain clones of B cells can be activated to produce antibodies.
14. All of the following pairing are correct except
(A) epitope-antigen (B) cytokines-TH cells
(C) interferons-virus infected cells (D) complement-TC cells
15. In which of the following situations will helper T cells be activated?
(A) when a cytotoxic T cell releases cytokines
(B) when an antigen is displayed by a dendritic cell
(C) when B cells respond to secret bantibodies
(D) when a macrophage responds to bind an antigens
16. Which statement about antibodies is false?
(A) Plasma cells are in charge o produce antibodies
(B) Foreign molecules can trigger the generation of antibodies
(C) An antibody has either two heavy chains or two light chains
(D) The structure of antibodies contains constant region and variable region
17. Naturally acquired passive immunity would involve the
(A) injection of antibodies (B) injection of interferon
(C) exposure of pathogens (D) placenta transfer of antibodies
18. Which of the following is a pathway that would lead to the activation of
plasma cells?
(A) APC cell contact antigen → helper T cell is activated → B cell activation
→ antibody production
(B) B cell contact antigen → helper T cell is activated → B cell clonal
selection → antibody production
(C) TC cells activation → MHC II/ antigen complex displayed → interleukin I
released → B cell binds with antigen → antibody production
(D) MHC I/ antigen complex displayed on cell surface → helper T cell is
activated → complement fixation → antibody production
19. All of the followings are autoimmune disease except
(A) Multiple sclerosis (B)Rheumatoid arthritis
(C) Systemic lupus erythematosus (D) graft-versus-host reaction
20. The following events occur when a mammalian immune system first encounters
a pathogen. Place them in correct sequence and then choose the answer that
indicates that squence.
I. pathogen is destroyed. II. lymphocytes secrete antibodies.
III. antigenic determinants from pathogen bind to antigen receptors on
lymphocytes.
IV. lymphocytes specific to antigenic determinants from pathogen become
numerous.
V. only memory cells remain.
(A) III-II-I-V-IV (B) III-I-II-IV-V (C) III-IV-II-I-V (D) III-IV-V-II-I