課程名稱︰分子生物學
課程性質︰必修
課程教師︰王愛玉/黃楓婷
開課學院：生命科學院
開課系所︰生化科技學系
考試日期（年月日）︰2016/11/07
考試時限（分鐘）：120分鐘
試題 :
（以下為本學期第二次期中考，由王愛玉老師與黃楓婷老師共同出題）
愛玉老師部分：佔50%
（事先公布試題，考試當天不得帶大抄）
有些疾病已知與DNA repair system無法正常運作有關。
請搜尋文獻，找出任五種與DNA repair缺失相關的疾病。
每種疾病10分，每一種疾病皆需敘述：
1) 此疾病的名稱及主要特徵 （2分）
2) 是導因於哪一種（或哪些）DNA repair system 發生問題？（寫出名稱即可）（2分）
3) 此 DNA repair system 正常機制為何？造成疾病的關鍵點為何？（6分）
楓婷老師部分：佔51%
1. In cells, what will be the effect if meiotic recombination does not occur?
(3%)
2. Please describe the six biological functions of homologous recombination.
(6%)
3. Please describe the differences between HR and CSSR. (Hint: Where? How?)
(6%)
4. Please describe and draw the three different types of site-specific
recombination. (6%)
5. Gene conversion usually occurs in different organisms with different
mechanisms. Please describe two types of gene conversion in detail.
(Hint: in HR and CSSR) (8%)
6. Transposition is carefully regulated in organisms to protect the chromosome
integrity. Please describe two types of mechanisms that transposition is
regulated, each with an example to illustrate in detail. (10%)
7. Please describe each step of the homologous recombination and write down
the proteins mainly responsible for each step in RecBCD pathway. (12%)