Re: [新聞] 巴西研究:羥氯奎寧治冠狀病毒無效

作者: douge (樹大便是美)   2020-07-25 01:03:32
※ 引述《leocean9816 (阿光)》之銘言:
: 1.媒體來源:CNA
: 2.記者署名:里約熱內盧24日綜合外電報導李昕頤
: 3.完整新聞標題:巴西研究:羥氯奎寧治冠狀病毒無效
: 4.完整新聞內文:
: 巴西研究人員今天發布的研究報告顯示,羥氯奎寧對2019冠狀病毒疾病輕中症患者並無療
: 效;此消息也直接打臉積極推廣使用羥氯奎寧的巴西總統波索納洛。
https://c19study.com/
這網頁統整了所有 HCQ研究發表文章的內容
這個研究今天出來
在連結的最上面
Late stage RCT of 667 hospitalized patients receiving up to 4 liters per
minute supplemental oxygen with up to 14 days from symptoms at enrollment,
not finding a significant effect after 15 days. 3 deaths (HCQ+AZ) vs. 5 (HCQ)
and 5 (control), too few for any conclusions.
Authors note: "our aim was to exclude patients already receiving longer and
potentially therapeutic doses of the study treatments." in explanation for
why the study protocol was changed to exclude patients with previous use of
the medications > 24hrs.
Authors note: "the trial cannot definitively rule out either a substantial
benefit of the trial drugs or a substantial harm". The trial had significant
protocol deviations and unusually low medication adherence. Randomization
resulted in 64.3% male patients (HCQ) vs. 54.2% (control) which may
significantly affect results due to the much higher risk for male patients.
The trial initially required enrollment within 48 hours of admission and was
changed to remove this requirement, which is likely to reduce effectiveness
since enrollment moved later after the time the disease became serious enough
for hospitalization.
The paper uses the terms mild and moderate, however all patients had serious
enough disease to be hospitalized, and 14% were actually randomized in the
ICU.
==============================================
看完你就知道 研究人員說的 跟這個新聞寫的內容
幾乎完全相反
現在正式發表而且有檢驗的文章都是說 HCQ有效
Yale 的流行病學教授 Dr. Harvey Risch 也跳出來說就是有效
不知道他是誰的 先看看他發表的文章
他剛好就是這些期刊的 Editor
https://scholar.google.com/citations?user=E1US9ucAAAAJ&hl=en
所以這個巴西的極少樣品的研究 經過媒體胡扯作者根本沒說的結果
以下請繼續
看不懂 看英文的黃色兩個字就知道了
作者: lsh77 (少問點)   2020-07-25 01:29:00
大哥上面寫not significant耶
作者: ayenyayaya (ayenya)   2020-07-25 01:54:00
他說沒結論
作者: mortleo (mort)   2020-07-25 02:05:00
Global HCQ studies. PrEP, PEP, and early treatment studies show high effectiveness, while late treatment shows mixed results.
作者: jabari (Still不敢開槍的娘娘腔)   2020-07-25 02:13:00
快死了投藥 沒救活帳記川普頭上 選我正解
作者: soyghcg (仙女撫我頂 結髮受長生)   2020-07-25 03:16:00
天朝很早就列入治療方案了 本來就有效了只是特性類似瑞德西偉 越早投藥越早減少轉重症變重症基本上就無效就是減少轉重症 但對重症死亡率減少沒顯著幫助一直放消息說無效就是藥商要賣瑞德西韋啊兩者87%像的東西 一個便宜到哭爸幾毛錢的東西一個貴到不行 療效類似 不打壓便宜學名藥貴的專利新藥怎麼賣

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