Position Summary:
The Jin Lab in the Department of Genetics at Washington University School of
Medicine is looking for an energetic and motivated individual to work as a
Postdoctoral Associate within a highly dynamic research team of scientists,
computational biologists, experimentalists, and clinicians.
The Jin Lab works at the intersection of genomics, human genetics,
pediatrics, and neuroscience. We are curious about many things and are
enthusiastic about what we do. We are currently focusing on the formulation,
development, and application of genetic, genomics, and bioinformatics methods
to better analyze and integrate genome and exome sequencing, SNP array,
RNA-sequencing, epigenomic, metabolomics, and proteomics data. Through the
integration of diverse types of transcriptomic and epigenetic functional
annotations, the integrative genomic analysis will provide a better
understanding of the molecular basis of cardiovascular diseases,
neurodevelopmental disorders, and neurodegenerative disorders, with a
specific focus on the interplay between rare protein-coding and
common-noncoding variants. We collaborate with clinicians, multiple genetic
consortia, the Undiagnosed Disease Network, and the Yale Center for Mendelian
Genomics to assemble thoroughly phenotyped cohorts for gene discovery and set
up a robust recruitment platform that includes domestic and international
collaboration and social media. Following integrative genomic analyses, we
use zebrafish to precisely model human mutations. We also collaborate with
experimentalists to design scalable high-throughput assays to model the
effects of disease-associated mutations using a model organism and/or
cell-based experiments to identify genes/pathways that affect disease
susceptibilities.
Dr. Jin’s research experience is available here: https://scjin.github.io/
Information on being a postdoc at Washington University in St. Louis can be
found at postdoc.wustl.edu/prospective-postdocs
Selected publications:
*Co-first authors
a. Jin SC*, J, Homsy J*, Zaidi S*, et al. Contribution of rare inherited
and de novo variants in 2,871 congenital heart disease probands. Nature
Genetics. 2017. PMID: 28991257. (Citations: >270)
b. Jin SC*, Lewis S*, Bakhtiari S*, Zeng X*, et al. Mutations disrupting
neuritogenesis genes confer risk for cerebral palsy. Nature Genetics. 2020.
PMID: 32989326.
c. Jin SC*, Dong W*, Kundishora AJ*, Panchagnula S*, Moreno-De-Luca A*, et
al. Exome sequencing implicates genetic disruption of prenatal
neuro-gliogenesis in sporadic congenital hydrocephalus. Nature Medicine.
2020. PMID: 33077954.
d. Duran D*, Zeng X*, Jin SC*, Choi J*, et al. Mutation in epigenetic
modifiers and signaling regulators of neurovascular development in Vein of
Galen malformation. Neuron. 2018. PMID: 30578106.
Required Qualifications:
1. The ideal applicant will hold a Ph.D. or MD/Ph.D., have prior research
experience in molecular biology, computational biology, genomics, biomedical
engineering, or related field.
2. We train postdocs with a biology background who would like to develop
bioinformatics skills.
3. We are equally interested in postdocs with a computer science background
who would like to apply these skills to studying human genetics and improving
personalized medicine.
4. The candidate will be expected to plan and carry out research tasks
independently and write-up/present findings on a regular basis.