※ 引述《endoutx (瘋騷大叔)》之銘言：
: 先說我不是來替廢物政府找藉口開脫的。
: 本肥是想問輝瑞口服藥是不是又來騙錢的？一個特效藥輕症吃可以89%防重症及死亡，聽起
: 來很屌，但實際上沒吃藥輕症率是99.76%，也就是只有0.24%會進到中重症（不排除未來會
: 飆高），那麼口服藥89%是防三小的？0.24%裡的89%？藥也貴森森的，為了救0.24%的89%要
: 給100%的人餵藥？你說是不是很騙錢？
: 再說口服藥限制一堆也很謎，本肥如果說能開發一種奇蹟口服藥能防99.9%重症死亡你信嗎
: ？只要在藥裡摻點各種慢性病吃了會母湯的成分，就能排除一堆本來就有病的老人了，其他
: 人吃了就算沒效用也不會重症，這樣是不是很賊？
: 總之我們廢物政府沒超前部署買到口服藥，說不定不是壞事，至少幫你省很多稅金，你看美
: 國確診就給藥還不是死一堆？大家覺得如何？
這個歐美已經有資料啦~
歐盟 (European Medicines Agency) 官網：
https://www.ema.europa.eu/en/medicines/human/EPAR/paxlovid
裡面What benefits of Paxlovid have been shown in studies?
A main study involving patients with COVID-19 and at least one underlying
condition putting them at risk of severe COVID-19 looked at the effects of
Paxlovid on rate of hospitalisation or death within 28 days of treatment
when compared with placebo (a dummy treatment). The analysis was done in
patients who received Paxlovid within 5 days after COVID-19 symptoms began
and who did not receive nor were expected to receive treatment with
antibodies. Over the month following treatment, the rate of hospitalisation
or death was 0.8% (8 out of 1,039) for patients who received Paxlovid,
compared with 6.3% (66 out of 1,046) for those who received placebo. There
were no deaths in the Paxlovid group and 12 deaths in the placebo group.
The majority of patients in the study were infected with the Delta variant.
Based on laboratory studies, Paxlovid is also expected to be active against
Omicron and other variants.
簡單翻譯重點：
針對有風險族群，在症狀發生五天內給藥，治療組1039人內有8人住院或死亡 (0.8%)
對照組(給安慰劑)1046人中有66人住院或死亡(6.3%)
在治療組中沒有病人死亡，而在對照組中有12人死亡
以上研究是針對delta變種，但也預期對omicron與其他變種有效
再補充一個研究 (NEJM) Nirmatrelvir是PaxLovid的成份之一
https://www.nejm.org/doi/full/10.1056/NEJMoa2118542
在最後分析
nirmatrelvir plus ritonavira (Paxlovid主成份)治療組
697人有5人住院(0.72%)、0人死亡(0%)
對照組682組中有44人住院 (6.45%)、9人死亡(1.32%)
結論：
Treatment of symptomatic Covid-19 with nirmatrelvir plus ritonavir
resulted in a risk of progression to severe Covid-19 that was 89%
lower than the risk with placebo, without evident safety concerns.
Paxlovid 當然不是神藥，也不是得病就非吃不可，
但當這些高風險病人一旦確診後，讓病人能選擇要不要接受藥物治療，不好嗎?
當然也可以批評omicron的輕症多，或藥物研究是用delta做的~ 但疫苗也是一樣啊?
雖然輕症多，現在指揮中心也是大力推行疫苗接種，而這些疫苗開發時delta還沒問世呢