辨認切割機制蠻多種的
zinc finger、TALEN到CRISPR-Cas9都是
簡單來說就是辨認序列 然後切掉他
http://www.nature.com/nprot/journal/v8/n11/full/nprot.2013.143.html
這是去年的nature protocal
有興趣可以參考看看
動物實驗已經在做了
但是要人體應用應該還很久
姑且不論該方法的問題(設計、辨認、剪切、脫鈀)
這等於要把一段外源性基因插入人體
這是最大的問題所在
※ 引述《Clementtang (劍客唐唐‧光明)》之銘言：
: 美國國家科學院學報 (Early Edition) 出版前預覽的最新文章
: http://www.pnas.org/content/early/2014/07/17/1405186111
: RNA-directed gene editing specifically eradicates latent and prevents new
: HIV-1 infection
: For more than three decades since the discovery of HIV-1, AIDS remains a
: major public health problem affecting greater than 35.3 million people
: worldwide. Current antiretroviral therapy has failed to eradicate HIV-1,
: partly due to the persistence of viral reservoirs. RNA-guided HIV-1 genome
: cleavage by the Cas9 technology has shown promising efficacy in disrupting
: the HIV-1 genome in latently infected cells, suppressing viral gene
: expression and replication, and immunizing uninfected cells against HIV-1
: infection. These properties may provide a viable path toward a permanent cure
: for AIDS, and provide a means to vaccinate against other pathogenic viruses.
: Given the ease and rapidity of Cas9/guide RNA development, personalized
: therapies for individual patients with HIV-1 variants can be developed
: instantly.
: 簡單來說，就是透過一種可以切 DNA 的蛋白質，把 HIV 基因從被感染的細胞，
: 例如微膠細胞 (microglia) 及 T 細胞 (T Cell) 切除，並能因此避免新 HIV 感染。
: 不過目前看來困難在怎麼在人體切到那些被感染的細胞，然後不會切錯 XD...